Windsor kidney researchers make game-changing discovery

Local researchers working with Windsor dialysis patients have made a groundbreaking discovery that could save the health-care system millions.

“This could be practice-changing throughout the world,” Windsor kidney specialist Dr. Albert Kadri said Friday, explaining the results of his team’s trial that examined the best dosage for an expensive clot-busting drug used to clear clogs in dialysis catheters.

Alteplase — a clot buster also used for strokes and heart attacks —  is the only drug used for this vital job, and up to now the proper dosage was undetermined, Kadri said. So most doctors went with the higher two milligram dose on each of the two catheters leading into and out of the dialysis machine that cleans the blood for people with kidney failure.

The study conducted in Windsor on about 50 local dialysis patients who use catheters showed that using a lower one mg dose works just as well, Kadri said. The results mean the cost of this drug can be cut in half to clear out catheters, something that has to be done as many as 25 times a year for some dialysis patients.

“The amount this medication is used is astronomical, and to cut the cost in half is crazy — it’s crazy,” he said, explaining that patients coming in multiple times per week for dialysis need the drug an average of at least 10 times a year.

Derrick Soong, a local pharmacist who participated in the study and works with dialysis patients, said a two mg treatment with the drug costs $120. The local dialysis centre spends $5,000 to $8,000 a month on Alteplase, so cutting dosage in half could save up to $50,000 a year, he said. And Windsor’s just an intermediate dialysis centre. Larger centres in Toronto would save much more.

If you multiply the savings across all the centres in Canada, the total would be significant, Soong said, explaining that the cost of the drug is borne by taxpayers. In the United States, there are many more dialysis patients and higher drug prices.

Windsor has about 400 dialysis patients and Ontario has more than 11,000, a number that’s been growing 3.3 per cent annually in recent years due to the aging population and rising rates of hypertension and diabetes that can lead to kidney failure. About 60 per cent of dialysis patients use catheters.

“The catheter is the lifeline for dialysis patients,” said Soong. “If the catheter doesn’t work, we can’t clean their blood,” and a patient could die as toxins build up in his or her body.

He said showing you need just half the dosage of this clot-busing drug “could be potentially a game-changer.”

The study, said Dr. Kadri, is the first randomized controlled trial spearheaded in Windsor and conducted solely in Windsor. It was funded by a grant of almost $100,000 from the Kidney Foundation of Canada.

The trial involved giving some patients 1 mg and others 2 mg, and monitoring the results, with neither the patients nor the researchers knowing the dosages until the final data was analyzed. The funding came after the same Windsor group did a retrospective study several years ago, which involved looking back at previous data.

The randomized controlled trial is the highest level of evidence you can get when you’re doing a study, said Kadri.

“We just finished it and we analyzed the data and the data actually showed us something that could be groundbreaking.”

The group, which also includes University of Windsor  nursing professor Maher El-Masri and pharmacist Wasim El Nekidy, is one of two local research projects asked to present their results at this fall’s conference of the American Society of Nephrology in New Orleans. As far as Kadri knows this is the first time Windsor-based research  has been presented at the conference.

The other presenter, Kadri’s nephrology colleague Dr. Syed Obaid Amin, is presenting his experience with a patient, a young man who’d been treated for a rare lymphoma (a cancer of the lymph nodes and lymphatic system) with a new chemo drug and ended up in renal failure with hard-to-treat hypertension.

This side effect had never been reported before with this particular drug called Potaninb, said Amin, who’ll relate to the conference the nature of the side effect and how he treated it. Amin arrived in Windsor from Ottawa a few months ago, so the patient he treated is from there. A CT scan showed that the blood vessels to the man’s kidneys had been blocked.

“After we stopped the drug and after we opened up his arteries by angioplasty, his kidney function got significantly better and he came off a lot of his blood pressure medication,” Amin said.

 


Story Source:

Materials provided by windsorstar

Note: Content may be edited for style and length.

Lab Findings Will Take Your Workouts to the Next Level

Khloe Kardashian has been hitting the gym hard and has not been letting herself slack, no matter what is going on in her life, as well as making sure that she sticks to a very strict diet. Khloe has since gone on to lose around 35lbs.

“Khloe gives as much to the gym as the gym gives to her”

Gunnar Peterson has praised Kardashian for her dedication. Her Beverly Hills-based trainer explains why Khloe’s physical transformation has been so major: “We keep her mind challenged and her body guessing, and the focus is on building strength. She never cancels! Some days it’s more heart-rate intensive, some days it’s more lower-extremities intensive, some days the upper extremities get a little extra love.”

p1
Khloe Kardashian

He added: “As the changes have come, the diet has tightened up … She’s made better choices when she eats. She’s been more conscious about working on sleep habits. She hydrates better. She keeps getting after it and she keeps getting better. We’re always playing with our workouts. We’re always making it that much more challenging. “And that hard work and intense focus has helped our September cover star score what some might call a post-breakup revenge body.

“Yeah, it’s a revenge body”

Khloe says, but it’s just as much for all my critics who called me ‘the fat one’ for my entire existance.” Her workout consists of a complete routine, two or three times a week, on nonconsecutive days. You can try it yourself!

Starting with the first exercise, do the prescribed number of reps, then rest 10 to 30 seconds. Do two to five sets of each move, then continue to the next move and repeat until you’ve done the entire routine. The biggest obstacle most people face when trying to add exercise into their day is time. Many also (mistakenly) think that the only way to stay fit is to hit the gym or spend at least an hour doing aerobic exercise. While it’s true that you increase your fitness level when you increase the intensity, frequency and duration of your program, it’s possible to gain moderate fitness benefits from making small, consistent changes to your daily life.

p2
Khloe Kardashian

The latest and probably one of the most common sense ways to get fit and lose excess body fat is by making painless additions of exercise to your day, combined with small diet modifications. For example, current research has shown that by consuming just 100 fewer calories per day, a woman can avoid the 1-2 pound gain most of us take on each year.

If you want to lose weight, you need to increase your daily caloric deduction by 500 calories, but you can do this by cutting 200 calories out of your daily diet and burning 300 calories more through exercise. Add that up over a week and you’ll have nearly a pound of fat loss with very little pain or diet deprivation. It’s the little things you do everyday that can make the difference between keeping fit or packing on!

Here are a few tips to help you find painless ways to stay fit:

All rise! The average person burns 100 calories per hour while sitting and 140 per hour while standing. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year. Stand while you talk on the phone and set up an area where you can work in a standing position (great for people with back pain!).

Take the stairs, not the elevator A 130-pound woman will burn nearly 20 calories each time she goes up and down the stairs. Do it all day watch how quickly those add up!

Dust while you talk on the phone. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year.

Lose the remote. Get up to change the channel! And while you’re up grab some weights for a set of bicep curls or shoulder presses. You can work through a full strength training routine in an hour if you do a set during each commercial.

Park so you have to walk. Don’t park your car in the closest spot to where you have to go, try and park as far as possible so you have to move your body as much as you can.

Walk and talk! Catch up on phone calls while your take a walk.

Be creative! Instead of thinking of all the ways you don’t have time to exercise, make it a game to see how many ways you can carve out time for little bouts of exercise. Lose your all or nothing mindset and look at exercise as a daily accumulation of activity.

p3
Khloe Kardashian

Remember, to lose weight you still need to take a look at your diet and try to eliminate excess calories, especially those that come from junk. Your goal isn’t difficult cutting 200-300 calories from your daily diet can be easy if you choose foods that you won’t miss too much. Think about switching from a can a soda every afternoon to unsweetened iced tea or a flavored sparkling water. But remember, don’t cut something that you look forward to everyday (for me cutting cream in my coffee would be a deal breaker), instead look for little changes you can make that won’t make a big difference in the foods your enjoy.

“We’re always playing with our workouts”

Hot on the heels of her steamy spread in Complex magazine, Khloe Kardashian has revealed she’s lost about 35 pounds from hitting the gym. The 31-year-old told Australian radio show “Fitzy & Wippa” on Friday about her weight loss journey. “I’ve lost like, 35 pounds. I don’t really weigh myself … but I know how I want to feel in clothes and it does become addicting once you start losing weight and seeing results. I want to see more,” she said.

p4
Khloe Kardashian

Kardashian recently slammed critics who accused her sexy shoot of being digitally altered, posting an un retouched photo alongside the one that appeared in the magazine.

loe Kardashian channeled her inner Beyonce by doing a booty pop on Instagram after her recent 13-pound weight loss. Khloe said Beyonce, who wowed fans with her sexy Met Gala ball gown, is her fitness inspiration.

“I just got my motivation for the year!” Kardashian gushed after seeing Beyonce’s super-fit body in a nude Givenchy dress. Beyonce has maintained her 65-pound post-baby weight loss with a vegan diet, according to her longtime trainer, Marco Borges.

Khloe posted several Instagram photos May 12, where she proudly showed off her tiny waist and toned booty. Kardashian previously revealed on Instagram that her weight loss secrets are a dairy-free diet, waist training and intense workouts with celebrity trainer Gunnar Peterson.

Peterson, who helped Khloe’s sister, Kim Kardashian, lose 56 pounds just six months after childbirth, said Khloe is extremely dedicated to diet and exercise. Peterson said Khloe has never looked better following her recent weight loss.

“Khloe’s a full-on animal in the gym”

“The changes she’s made to her body are incredible. She’s done it the right way. Nothing fast, just hard work. Her body is bangin’ right now.”

Khloe gets laser treatments to zap the cellulite off her butt and thighs, but said the rest of her body is all-natural, not due to plastic surgery. Kardashian feels great after losing 13 pounds recently by following a dairy-free diet and exercising five days a week.

10 Foods that Promote Weight Loss and Health

Khloe Kardashian has been hitting the gym hard and has not been letting herself slack, no matter what is going on in her life, as well as making sure that she sticks to a very strict diet. Khloe has since gone on to lose around 35lbs.

“Khloe gives as much to the gym as the gym gives to her”

Gunnar Peterson has praised Kardashian for her dedication. Her Beverly Hills-based trainer explains why Khloe’s physical transformation has been so major: “We keep her mind challenged and her body guessing, and the focus is on building strength. She never cancels! Some days it’s more heart-rate intensive, some days it’s more lower-extremities intensive, some days the upper extremities get a little extra love.”

p1
Khloe Kardashian

He added: “As the changes have come, the diet has tightened up … She’s made better choices when she eats. She’s been more conscious about working on sleep habits. She hydrates better. She keeps getting after it and she keeps getting better. We’re always playing with our workouts. We’re always making it that much more challenging. “And that hard work and intense focus has helped our September cover star score what some might call a post-breakup revenge body.

“Yeah, it’s a revenge body”

Khloe says, but it’s just as much for all my critics who called me ‘the fat one’ for my entire existance.” Her workout consists of a complete routine, two or three times a week, on nonconsecutive days. You can try it yourself!

Starting with the first exercise, do the prescribed number of reps, then rest 10 to 30 seconds. Do two to five sets of each move, then continue to the next move and repeat until you’ve done the entire routine. The biggest obstacle most people face when trying to add exercise into their day is time. Many also (mistakenly) think that the only way to stay fit is to hit the gym or spend at least an hour doing aerobic exercise. While it’s true that you increase your fitness level when you increase the intensity, frequency and duration of your program, it’s possible to gain moderate fitness benefits from making small, consistent changes to your daily life.

p2
Khloe Kardashian

The latest and probably one of the most common sense ways to get fit and lose excess body fat is by making painless additions of exercise to your day, combined with small diet modifications. For example, current research has shown that by consuming just 100 fewer calories per day, a woman can avoid the 1-2 pound gain most of us take on each year.

If you want to lose weight, you need to increase your daily caloric deduction by 500 calories, but you can do this by cutting 200 calories out of your daily diet and burning 300 calories more through exercise. Add that up over a week and you’ll have nearly a pound of fat loss with very little pain or diet deprivation. It’s the little things you do everyday that can make the difference between keeping fit or packing on!

Here are a few tips to help you find painless ways to stay fit:

All rise! The average person burns 100 calories per hour while sitting and 140 per hour while standing. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year. Stand while you talk on the phone and set up an area where you can work in a standing position (great for people with back pain!).

Take the stairs, not the elevator A 130-pound woman will burn nearly 20 calories each time she goes up and down the stairs. Do it all day watch how quickly those add up!

Dust while you talk on the phone. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year.

Lose the remote. Get up to change the channel! And while you’re up grab some weights for a set of bicep curls or shoulder presses. You can work through a full strength training routine in an hour if you do a set during each commercial.

Park so you have to walk. Don’t park your car in the closest spot to where you have to go, try and park as far as possible so you have to move your body as much as you can.

Walk and talk! Catch up on phone calls while your take a walk.

Be creative! Instead of thinking of all the ways you don’t have time to exercise, make it a game to see how many ways you can carve out time for little bouts of exercise. Lose your all or nothing mindset and look at exercise as a daily accumulation of activity.

p3
Khloe Kardashian

Remember, to lose weight you still need to take a look at your diet and try to eliminate excess calories, especially those that come from junk. Your goal isn’t difficult cutting 200-300 calories from your daily diet can be easy if you choose foods that you won’t miss too much. Think about switching from a can a soda every afternoon to unsweetened iced tea or a flavored sparkling water. But remember, don’t cut something that you look forward to everyday (for me cutting cream in my coffee would be a deal breaker), instead look for little changes you can make that won’t make a big difference in the foods your enjoy.

“We’re always playing with our workouts”

Hot on the heels of her steamy spread in Complex magazine, Khloe Kardashian has revealed she’s lost about 35 pounds from hitting the gym. The 31-year-old told Australian radio show “Fitzy & Wippa” on Friday about her weight loss journey. “I’ve lost like, 35 pounds. I don’t really weigh myself … but I know how I want to feel in clothes and it does become addicting once you start losing weight and seeing results. I want to see more,” she said.

p4
Khloe Kardashian

Kardashian recently slammed critics who accused her sexy shoot of being digitally altered, posting an un retouched photo alongside the one that appeared in the magazine.

loe Kardashian channeled her inner Beyonce by doing a booty pop on Instagram after her recent 13-pound weight loss. Khloe said Beyonce, who wowed fans with her sexy Met Gala ball gown, is her fitness inspiration.

“I just got my motivation for the year!” Kardashian gushed after seeing Beyonce’s super-fit body in a nude Givenchy dress. Beyonce has maintained her 65-pound post-baby weight loss with a vegan diet, according to her longtime trainer, Marco Borges.

Khloe posted several Instagram photos May 12, where she proudly showed off her tiny waist and toned booty. Kardashian previously revealed on Instagram that her weight loss secrets are a dairy-free diet, waist training and intense workouts with celebrity trainer Gunnar Peterson.

Peterson, who helped Khloe’s sister, Kim Kardashian, lose 56 pounds just six months after childbirth, said Khloe is extremely dedicated to diet and exercise. Peterson said Khloe has never looked better following her recent weight loss.

“Khloe’s a full-on animal in the gym”

“The changes she’s made to her body are incredible. She’s done it the right way. Nothing fast, just hard work. Her body is bangin’ right now.”

Khloe gets laser treatments to zap the cellulite off her butt and thighs, but said the rest of her body is all-natural, not due to plastic surgery. Kardashian feels great after losing 13 pounds recently by following a dairy-free diet and exercising five days a week.

Adventures that You Can Try with Your Family

Khloe Kardashian has been hitting the gym hard and has not been letting herself slack, no matter what is going on in her life, as well as making sure that she sticks to a very strict diet. Khloe has since gone on to lose around 35lbs.

“Khloe gives as much to the gym as the gym gives to her”

Gunnar Peterson has praised Kardashian for her dedication. Her Beverly Hills-based trainer explains why Khloe’s physical transformation has been so major: “We keep her mind challenged and her body guessing, and the focus is on building strength. She never cancels! Some days it’s more heart-rate intensive, some days it’s more lower-extremities intensive, some days the upper extremities get a little extra love.”

p1
Khloe Kardashian

He added: “As the changes have come, the diet has tightened up … She’s made better choices when she eats. She’s been more conscious about working on sleep habits. She hydrates better. She keeps getting after it and she keeps getting better. We’re always playing with our workouts. We’re always making it that much more challenging. “And that hard work and intense focus has helped our September cover star score what some might call a post-breakup revenge body.

“Yeah, it’s a revenge body”

Khloe says, but it’s just as much for all my critics who called me ‘the fat one’ for my entire existance.” Her workout consists of a complete routine, two or three times a week, on nonconsecutive days. You can try it yourself!

Starting with the first exercise, do the prescribed number of reps, then rest 10 to 30 seconds. Do two to five sets of each move, then continue to the next move and repeat until you’ve done the entire routine. The biggest obstacle most people face when trying to add exercise into their day is time. Many also (mistakenly) think that the only way to stay fit is to hit the gym or spend at least an hour doing aerobic exercise. While it’s true that you increase your fitness level when you increase the intensity, frequency and duration of your program, it’s possible to gain moderate fitness benefits from making small, consistent changes to your daily life.

p2
Khloe Kardashian

The latest and probably one of the most common sense ways to get fit and lose excess body fat is by making painless additions of exercise to your day, combined with small diet modifications. For example, current research has shown that by consuming just 100 fewer calories per day, a woman can avoid the 1-2 pound gain most of us take on each year.

If you want to lose weight, you need to increase your daily caloric deduction by 500 calories, but you can do this by cutting 200 calories out of your daily diet and burning 300 calories more through exercise. Add that up over a week and you’ll have nearly a pound of fat loss with very little pain or diet deprivation. It’s the little things you do everyday that can make the difference between keeping fit or packing on!

Here are a few tips to help you find painless ways to stay fit:

All rise! The average person burns 100 calories per hour while sitting and 140 per hour while standing. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year. Stand while you talk on the phone and set up an area where you can work in a standing position (great for people with back pain!).

Take the stairs, not the elevator A 130-pound woman will burn nearly 20 calories each time she goes up and down the stairs. Do it all day watch how quickly those add up!

Dust while you talk on the phone. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year.

Lose the remote. Get up to change the channel! And while you’re up grab some weights for a set of bicep curls or shoulder presses. You can work through a full strength training routine in an hour if you do a set during each commercial.

Park so you have to walk. Don’t park your car in the closest spot to where you have to go, try and park as far as possible so you have to move your body as much as you can.

Walk and talk! Catch up on phone calls while your take a walk.

Be creative! Instead of thinking of all the ways you don’t have time to exercise, make it a game to see how many ways you can carve out time for little bouts of exercise. Lose your all or nothing mindset and look at exercise as a daily accumulation of activity.

p3
Khloe Kardashian

Remember, to lose weight you still need to take a look at your diet and try to eliminate excess calories, especially those that come from junk. Your goal isn’t difficult cutting 200-300 calories from your daily diet can be easy if you choose foods that you won’t miss too much. Think about switching from a can a soda every afternoon to unsweetened iced tea or a flavored sparkling water. But remember, don’t cut something that you look forward to everyday (for me cutting cream in my coffee would be a deal breaker), instead look for little changes you can make that won’t make a big difference in the foods your enjoy.

“We’re always playing with our workouts”

Hot on the heels of her steamy spread in Complex magazine, Khloe Kardashian has revealed she’s lost about 35 pounds from hitting the gym. The 31-year-old told Australian radio show “Fitzy & Wippa” on Friday about her weight loss journey. “I’ve lost like, 35 pounds. I don’t really weigh myself … but I know how I want to feel in clothes and it does become addicting once you start losing weight and seeing results. I want to see more,” she said.

p4
Khloe Kardashian

Kardashian recently slammed critics who accused her sexy shoot of being digitally altered, posting an un retouched photo alongside the one that appeared in the magazine.

loe Kardashian channeled her inner Beyonce by doing a booty pop on Instagram after her recent 13-pound weight loss. Khloe said Beyonce, who wowed fans with her sexy Met Gala ball gown, is her fitness inspiration.

“I just got my motivation for the year!” Kardashian gushed after seeing Beyonce’s super-fit body in a nude Givenchy dress. Beyonce has maintained her 65-pound post-baby weight loss with a vegan diet, according to her longtime trainer, Marco Borges.

Khloe posted several Instagram photos May 12, where she proudly showed off her tiny waist and toned booty. Kardashian previously revealed on Instagram that her weight loss secrets are a dairy-free diet, waist training and intense workouts with celebrity trainer Gunnar Peterson.

Peterson, who helped Khloe’s sister, Kim Kardashian, lose 56 pounds just six months after childbirth, said Khloe is extremely dedicated to diet and exercise. Peterson said Khloe has never looked better following her recent weight loss.

“Khloe’s a full-on animal in the gym”

“The changes she’s made to her body are incredible. She’s done it the right way. Nothing fast, just hard work. Her body is bangin’ right now.”

Khloe gets laser treatments to zap the cellulite off her butt and thighs, but said the rest of her body is all-natural, not due to plastic surgery. Kardashian feels great after losing 13 pounds recently by following a dairy-free diet and exercising five days a week.

Discover How Yoga Benefits Your Proffessional Growth

Khloe Kardashian has been hitting the gym hard and has not been letting herself slack, no matter what is going on in her life, as well as making sure that she sticks to a very strict diet. Khloe has since gone on to lose around 35lbs.

“Khloe gives as much to the gym as the gym gives to her”

Gunnar Peterson has praised Kardashian for her dedication. Her Beverly Hills-based trainer explains why Khloe’s physical transformation has been so major: “We keep her mind challenged and her body guessing, and the focus is on building strength. She never cancels! Some days it’s more heart-rate intensive, some days it’s more lower-extremities intensive, some days the upper extremities get a little extra love.”

p1
Khloe Kardashian

He added: “As the changes have come, the diet has tightened up … She’s made better choices when she eats. She’s been more conscious about working on sleep habits. She hydrates better. She keeps getting after it and she keeps getting better. We’re always playing with our workouts. We’re always making it that much more challenging. “And that hard work and intense focus has helped our September cover star score what some might call a post-breakup revenge body.

“Yeah, it’s a revenge body”

Khloe says, but it’s just as much for all my critics who called me ‘the fat one’ for my entire existance.” Her workout consists of a complete routine, two or three times a week, on nonconsecutive days. You can try it yourself!

Starting with the first exercise, do the prescribed number of reps, then rest 10 to 30 seconds. Do two to five sets of each move, then continue to the next move and repeat until you’ve done the entire routine. The biggest obstacle most people face when trying to add exercise into their day is time. Many also (mistakenly) think that the only way to stay fit is to hit the gym or spend at least an hour doing aerobic exercise. While it’s true that you increase your fitness level when you increase the intensity, frequency and duration of your program, it’s possible to gain moderate fitness benefits from making small, consistent changes to your daily life.

p2
Khloe Kardashian

The latest and probably one of the most common sense ways to get fit and lose excess body fat is by making painless additions of exercise to your day, combined with small diet modifications. For example, current research has shown that by consuming just 100 fewer calories per day, a woman can avoid the 1-2 pound gain most of us take on each year.

If you want to lose weight, you need to increase your daily caloric deduction by 500 calories, but you can do this by cutting 200 calories out of your daily diet and burning 300 calories more through exercise. Add that up over a week and you’ll have nearly a pound of fat loss with very little pain or diet deprivation. It’s the little things you do everyday that can make the difference between keeping fit or packing on!

Here are a few tips to help you find painless ways to stay fit:

All rise! The average person burns 100 calories per hour while sitting and 140 per hour while standing. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year. Stand while you talk on the phone and set up an area where you can work in a standing position (great for people with back pain!).

Take the stairs, not the elevator A 130-pound woman will burn nearly 20 calories each time she goes up and down the stairs. Do it all day watch how quickly those add up!

Dust while you talk on the phone. Get on your feet two hours a day while you work and you could drop 6 pounds over the course of a year.

Lose the remote. Get up to change the channel! And while you’re up grab some weights for a set of bicep curls or shoulder presses. You can work through a full strength training routine in an hour if you do a set during each commercial.

Park so you have to walk. Don’t park your car in the closest spot to where you have to go, try and park as far as possible so you have to move your body as much as you can.

Walk and talk! Catch up on phone calls while your take a walk.

Be creative! Instead of thinking of all the ways you don’t have time to exercise, make it a game to see how many ways you can carve out time for little bouts of exercise. Lose your all or nothing mindset and look at exercise as a daily accumulation of activity.

p3
Khloe Kardashian

Remember, to lose weight you still need to take a look at your diet and try to eliminate excess calories, especially those that come from junk. Your goal isn’t difficult cutting 200-300 calories from your daily diet can be easy if you choose foods that you won’t miss too much. Think about switching from a can a soda every afternoon to unsweetened iced tea or a flavored sparkling water. But remember, don’t cut something that you look forward to everyday (for me cutting cream in my coffee would be a deal breaker), instead look for little changes you can make that won’t make a big difference in the foods your enjoy.

“We’re always playing with our workouts”

Hot on the heels of her steamy spread in Complex magazine, Khloe Kardashian has revealed she’s lost about 35 pounds from hitting the gym. The 31-year-old told Australian radio show “Fitzy & Wippa” on Friday about her weight loss journey. “I’ve lost like, 35 pounds. I don’t really weigh myself … but I know how I want to feel in clothes and it does become addicting once you start losing weight and seeing results. I want to see more,” she said.

p4
Khloe Kardashian

Kardashian recently slammed critics who accused her sexy shoot of being digitally altered, posting an un retouched photo alongside the one that appeared in the magazine.

loe Kardashian channeled her inner Beyonce by doing a booty pop on Instagram after her recent 13-pound weight loss. Khloe said Beyonce, who wowed fans with her sexy Met Gala ball gown, is her fitness inspiration.

“I just got my motivation for the year!” Kardashian gushed after seeing Beyonce’s super-fit body in a nude Givenchy dress. Beyonce has maintained her 65-pound post-baby weight loss with a vegan diet, according to her longtime trainer, Marco Borges.

Khloe posted several Instagram photos May 12, where she proudly showed off her tiny waist and toned booty. Kardashian previously revealed on Instagram that her weight loss secrets are a dairy-free diet, waist training and intense workouts with celebrity trainer Gunnar Peterson.

Peterson, who helped Khloe’s sister, Kim Kardashian, lose 56 pounds just six months after childbirth, said Khloe is extremely dedicated to diet and exercise. Peterson said Khloe has never looked better following her recent weight loss.

“Khloe’s a full-on animal in the gym”

“The changes she’s made to her body are incredible. She’s done it the right way. Nothing fast, just hard work. Her body is bangin’ right now.”

Khloe gets laser treatments to zap the cellulite off her butt and thighs, but said the rest of her body is all-natural, not due to plastic surgery. Kardashian feels great after losing 13 pounds recently by following a dairy-free diet and exercising five days a week.

What Drinking Coffee Actually Does To Your Body

Whether you just like the taste of coffee, drink it out of habit, or truly rely on it for energy, it’s no secret the drink has magical powers. But have you ever thought about what it’s actually doing after you gulp down your morning mug?

Coffee comes from a bean, so it contains phytonutrients and polyphenols, chemical compounds found in plants that are believed to have antioxidant benefits, Dana Hunnes, Ph.D., M.P.H., R.D., senior dietician at UCLA Medical Center and adjunct assistant professor at the Fielding School of Public Health, tells SELF. “But for the most part, caffeine tends to be the nutrient in coffee that people are most aware of and that’s the best studied.”

From your brain to your bowels, coffee does work on your body. Here’s what’s really happening when you drink it.

The caffeine enters your bloodstream and quickly finds its way to your brain, where it works as a stimulant and boosts alertness and energy.

“The chemical enters your bloodstream fairly quickly,” Hunnes says. It can take as few as 10 minutes from drinking for caffeine to start working. Caffeine binds to adenosine receptors in the brain. Adenosine is a nervous system depressant, meaning its presence suppresses arousal and promotes sleep. When caffeine intrudes and binds to the receptors, adenosine’s effects are lessened, and we become stimulated. This increased brain activity then stimulates the release of adrenaline, which is what gives us that big burst of energy and attentiveness associated with a morning cup of Joe. Studiesalso have connected caffeine consumption to a boost in memory.

The downside is that drinking too much can cause insomnia.

“If you have caffeine later in the day, it can actually predispose you to develop insomnia or make it worse if you already have it,” Rachel Salas, M.D., an associate professor of neurology at Johns Hopkins Medicine who specializes in sleep medicine, tells SELF. It can keep anyone up if they drink it too close to bedtime, but if you’re prone to develop insomnia, a coffee habit can be the trigger that causes a chronic problem. Salas suggests stopping coffee (and all other caffeine) consumption at noon if you think it may be impacting your ability to fall asleep at night. If you can’t function before your morning cup, it’s a red flag you need to take a look at your sleep habits. Coffee is a helpful crutch when you’re tired, but it’s not going to actually give you more energy in the long term. Only good sleep can do that.

That’s partially because caffeine stays in your system for hours and hours.

“The way we metabolize coffee is called a half-life,” Hunnes says. In most people, caffeine’s half-life is 4 to 6 hours. “It takes about 6 hours to reduce the amount of caffeine in our blood by about 50 percent,” she explains. So if you drink a 200 mg cup at 9 AM, by 3 PM you’ll have 100 mg left, and by 9 PM you’ll have 50 mg. Keep in mind, that’s the average half-life—how quickly you metabolize caffeine really depends on your individual body chemistry and genetics.

Caffeine also impacts our pleasure centers, which improves our mood…and keeps us hooked.

“It can help you be more alert and reactive, but it can also help pep you up and impact your mood,” Salas says. Like most drugs, caffeine in coffee increases the levels of feel-good chemical dopamine in our brains. (Other stimulants like cocaine have the same effect, but just much stronger.) This can improve our moods and increase happiness. But for daily drinkers, this can create dependence, resulting in withdrawal symptoms when you go without—it’s why habitual users tend to wake up grumpy and get headaches if they don’t get their fix.

Too much caffeine can have a negative impact on mood and mental health.

High doses can mess with your brain chemistry too much, and cause jitteriness and nervousness. Studies have shown that high doses of caffeine can increase anxiety and panic attacks. Those who already struggle with these mental health challenges tend to be more sensitive to caffeine and its mood-altering effects.

Drinking large amounts of coffee can cause a spike in blood pressure and heart rate.

Studies have suggested that coffee increases heart rate, thanks to caffeine’s impact on hormones and neurotransmitters. But drinking coffee in moderation—one to three cups per day–shouldn’t have a noticeable impact on a healthy adult. According to the Mayo Clinic, some habitual drinkers may have a slightly higher blood pressure, while others develop a tolerance and are not affected in the long term. There isn’t a clear explanation as to why caffeine causes this increase in blood pressure, but it’s likely due to increased adrenaline and other hormonal responses brought on by the stimulant.

Coffee stimulates bowel movements, and may even reduce the risk of gallstones.

Ever notice you really have to hit the bathroom after a cup of coffee? Experts believe caffeine directly stimulates the colonic muscles, prompting bowel movements. Plus, if you’re drinking it hot, the warm liquid itself can help relax the colon and prompt muscle contractions, adding to the laxative effect. When the muscles in the gallbladder specifically are stimulated, it increases emptying, which can reduce the risk of gallstones.

It’s a myth that coffee is dehydrating.

“It’s a very mild diuretic,” Hunnes says. “But it’s not really much of a dehydrator.” She says that if you were to drink a huge amount in one day, say 8 cups (which is not recommended), and have no other fluids all day, you might experience slight dehydration. But coffee contains a lot of water, and it counts toward your daily fluid intake just like a plain glass of H2O would.

Coffee may suppress appetite and boost calorie burn, but it’s not a magic weight-loss bullet (sorry).

Coffee is a known appetite suppressant and may stimulate thermogenesis, or the process our bodies use to create heat, which theoretically leads us to burn more calories. But there’s not much evidence that these effects are large enough to result in significant or long-term weight loss, the Mayo Clinic says. Black coffee is a good low-cal way to get your fix, but choking it down for its supposed weight-loss benefits probably won’t bring any noticeable changes.

Sports Illustrated Swimsuit Model Marisa Miller’s Bikini Photos and Secrets to Supermodel Success

Marisa Miller may look like an angel—she is, after all, a Victoria’s Secret supermodel (and Sports Illustrated swimsuit cover girl)—but she’s as down-to-earth as they come. Her combination of girly-girl meets tomboy makes her ideal for the cover of SHAPE—in fact, she’s had that honor eight times. “It’s funny that I’m the one giving advice now,” says the 32-year-old, “I’ve been turning to SHAPE for workout tips since I was 20. I really hope I can inspire other women to be the best that they can be.”

Get inspired by Marisa as she reveals some of the unique qualities that help make her such a successful and respected supermodel and role model.

http://www.onthespot247.com/top-bikini-models-of-all-time-where-are-they-now/

Top Bikini Models of All Time: Where Are They Now?

Bikini Models: Heidi Klum Then

Heidi Klum is the definitive hot bikini model. The German beauty was a fan favorite in Sports Illustrated’s Swimsuit Edition and one of Victoria’s Secret’s most famous Angels. Here, Heidi walks the runway at the 2003 Victoria’s Secret Fashion Show.

Bikini Models: Heidi Klum Now

Heidi Klum’s career just won’t stop. The mother of four is the host, judge and executive producer ofProject Runway and has her own line of jewelry, as well as various clothing lines and fragrances. Still, Heidi manages to stay in amazing shape, and she is fighting to end heart disease, too. Check out our exclusive Q&A with the multitasking model.

Bikini Models: Naomi Campbell Then

Naomi Campbell was one of the most recognizable faces (and bodies) during the supermodel era of the early 90s. Discovered at the age of 15, the British model worked the runway (seen here in a bikini from Chanel’s 1994 ready-to-wear collection), starred in numerous music videos and broke fashion’s color barrier by being one of the first black models to make the cover of many magazines.

Bikini Models: Naomi Campbell Now

Naomi Campbell remains a force to be reckoned with in the fashion world. She is still a presence on the runway and a contributing editor for several high fashion publications. While not without her share of controversies and legal battles, Naomi does extensive charity work. Make your workout do double duty with these fit events that raise money for a good cause.

Bikini Models: Kathy Ireland Then

In 1989 Kathy Ireland appeared on the cover of SI‘s most popular Swimsuit Edition ever—which is why she was featured in 13 consecutive issues after that. The California native started an acting career in the late 80s and founded Kathy Ireland Worldwide in the early 90s. Here, Kathy shows off the 1998 version of her bikini body.

Bikini Models: Kathy Ireland Now

The success of Kathy Ireland Worldwide (the company brings in a reported $1.5 billion each year) prompted Forbes to call Kathy the “prototype for model-turned mogul.” Kathy is also the author of six books, including one about her 25-pound weight gain and loss. Kathy’s not the only celeb who has transformed her body. See more of Hollywood’s most dramatic before and after photos.

Bikini Models: Molly Sims Then

Molly Sims started her modeling career later than most of the bikini models featured on our list, but we couldn’t leave out this Kentucky native’s perfect beach body. In 2000, the former host of MTV’s House of Style made her first appearance in SI‘s Swimsuit Edition. Molly is seen here at MTV’s Fashionably Loud presents the Sports Illustrated 2002 Swimsuit Issue – Show.

Bikini Models: Molly Sims Now

Molly Sims made a smooth transition from modeling to acting and went on to star in all five seasons of NBC’s Las Vegas. Molly added designer to her credentials in 2010, launching her own jewelry line. The 37-year-old works out with celeb trainer Tracy Anderson to stay in amazing shape. Steal the best stay-fit tips from more of Hollywood’s top trainers.

Bikini Models: Rebecca Romijn Then

Rebecca Romijn began her modeling career in 1991, working the runway and starring in ad campaigns for Victoria’s Secret. The blonde bombshell was on the cover of the 1999 SI Swimsuit Edition. Here, Rebecca Romijn poses for a ‘Got Milk’ ad in New York’s Time Square in 1998.

Bikini Models: Rebecca Romijn Now

Rebecca Romijn’s successful acting career almost makes us forget that it wasn’t her first job. The wife and mother of two starred in three X-Men movies (2000, 2003, 2006) and was nominated for a Screen Actors Guild award for her role on ABC’s Ugly Betty. Rebecca takes long hikes and bike rides with her family. If you like being active with your family,consider one of these four fit getaways.

Bikini Models: Christie Brinkley Then

Christie Brinkley’s 20-year contract with CoverGirl is the longest in modeling history. The California surfer girl has appeared on more than 500 magazine covers, including SI‘s Swimsuit Edition for three consecutive years (1979, 1980, 1981). Brinkley is seen here in 1983 in a still from National Lampoon’s Vacation.

Bikini Models: Christie Brinkley Now

Over time, Christie Brinkley dabbled in acting, illustrating, writing and designing, in addition to her involvement in many worldwide charities. The 56-year-old mother of three is still a knockout, finding creative ways to work exercise into her daily routine.In this exclusive interview, Christie reveals the diet that keeps her looking this amazing.

Bikini Models: Tyra Banks Then

Tyra Banks signed her first modeling contract at age 17 and then booked a record 25 fashion shows during her first week in Paris. Tyra was the first African American to appear on the cover of GQ and the SI Swimsuit Edition. Here, Tyra walks the runway in the 2003 Victoria’s Secret Spring Fashion show.

Bikini Models: Tyra Banks Now

Pia Wurtzbach’s Sexy Pics Draws Netizens’ Attention to HIV AIDS

Miss Universe 2016 Pia Alonzo Wurtzbach isn’t one to shy away from showing off her sexy and trimmed body on social media.

Last week, the Filipina beauty queen caught the attention of her followers in a black swimsuit—all for her dedication to HIV/AIDS awareness.

According to Pia in an Instagram post on Saturday, “NOW that I have your attention, do you know your status yet? Cos I know mine. Not your relationship status, silly! I meant HIV status.”

Since her crowning as Miss Universe in December, Pia has gained global attention for her advocacies, including HIV/AIDS awareness and gender equality.

Last June, she went to the Apicha Community Health Center (Apicha CHC) in New York City to have herself tested for HIV/AIDS.

While she has not revealed her status to the public since the testing, the titleholder insisted that it really shouldn’t matter.

According to the Filipina beauty queen, “What if I say ‘positive’? Are you going to be disgusted? Does that mean I’m a horrible person? Hmmm. That’s where the discrimination comes in. My point is: Know your status. My question was ‘Do you know your status’ and not ‘What’s your status?’ There’s a difference.”

In an interview with advocacy group amfAR when she returned to New York, she said that she wants to use the attention she has received as Miss Universe to direct people towards important issues, such as battling the rise of HIV/AIDS cases by breaking down taboos and urging the government to be more vigilant about human traffic and rampant drug use.This All Pics On Instgram piawurtzbach

Science Confirms You Drink More Alcohol When You’re Single

This new study explains why I’m drunk AF every weekend.

According to new research, there is “strong evidence that intimate relationships cause a decline in alcohol consumption.”

Diana Dinescu, a psychologist at the University of Virginia, writes in the Journal of Family Psychology that married people have a ton of benefits that single people do not, including the newfound fact that married people drink less than people who are single or divorced.

The study analyzed the drinking habits of 2,425 twins of the same sex, and compared them to those of twins who were single or divorced, as well cohabiting twins. The co-twins who were married both drank less frequently and drank fewer alcoholic beverages than their single co-twin counterparts.

There might be a loophole in the findings, though. For example, it could very well be possible that those who don’t drink much are just more likely to get married, not the other way around.

Still, there has to be a reason for why married people are less inclined to go for a drink. Dinescu points out that husbands and wives “may monitor each other’s behavior, support positive coping, alter each other’s values and encourage delayed gratification more generally.” Married people also probably spend less time out and more time at home.

I guess that makes sense. Single people don’t necessarily have other people looking out for them and their alcohol consumption. If anything, friends are enablers of my drinking habits.

This study only confirms research we found last week, which found that single people spend way more money per month than people in relationships do (specifically, about $630). That’s partly because single people drink about three times as much as coupled-up folks.

The researchers boiled this conclusion down to the fact that couples usually split the drink bills when they go out, while single people have to fend for themselves (unless, of course, you’re skilled and can get guys to buy you drinks all the time).

So, if you find a partner you love enough to marry, you can bet on the fact you won’t wake up hungover all the time. I know, I know, finding the love of your life is way harder than it sounds.