New pill could help Alzheimer’s patients


PHOENIX – It was just last week that the world said goodbye to the Rhinestone Cowboy. Country music star Glen Campbell passed away after a long battle with Alzheimer’s Disease. For the millions of Americans with the same diagnosis, there’s not much the medical world can do to help, but there’s a new drug being tested right now that could change lives.

On a Thursday afternoon, Doctor William Burke is making his rounds at the Banner Alzheimer’s Institute in Phoenix. One of his patients is Diane Scheel. She was diagnosed with the disease in 2012.

“It was really hard on me,” says Scheel. She’s 61. She’s already stopped driving and even had to give up being a dental hygienist – a career she had for 30 years.

“I was always active and everything like that and I never would have thought in a million years that I would have it – but it was there.”

The fact is, there are five million Americans right now living with Alzheimer’s. About 130,000 are right here in Arizona. This year the disease will cost the nation $259 billion. By 2050 the cost will go up to $1.1 trillion according to the Alzheimer’s Association.

Right now there are two FDA-approved drugs that help control the disease. You take them at the same time. Banner is testing a third pill to see if it will help those other drugs work better.

“It has been a decade since there’s been anything new approved so this would be the third medication,” said Dr. Burke.

According to the Alzheimer’s Association, since 2000, deaths from heart disease have decreased by 14 percent while deaths from Alzheimer’s have increased by 89 percent.

Scheel is on the clinical trial and is hoping the new drug will work for her and everyone else battling the same thing. “I’m stronger than I thought I was,” said Scheel. “But it was hard because there was a lot of tears – but I think I can handle it.”

Interested people and caregivers interested in participating in the SUVN-502 study can contact Banner Alzheimer’s Institute in Phoenix by calling 602-839-4894, or Banner Sun Health in Sun City at 623-832-6530.


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Losing sense of smell could signal Alzheimer’s: McGill researchers

If you have a hard time identifying specific smells, it could be a sign that you are at risk for developing Alzheimer’s disease, a group of McGill researchers has found.

The study, published in the journal Neurology, looked at whether a simple smell test could reveal someone’s susceptibility to the disease.

“Despite all the research in the area, no effective treatment has yet been found for Alzheimer’s disease,” John Breitner, one of the study’s authors, said in a statement. He is the director of the Centre for Studies on Prevention of Alzheimer’s Disease at the Douglas Mental Health Research Centre of McGill University.

“But, if we can delay the onset of symptoms by just five years, we should be able to reduce the prevalence and severity of these symptoms by more than 50 per cent,” Breitner added.

The study looked at nearly 300 people, with an average age of 63, who were considered at risk of developing Alzheimer’s because they had a parent who had the disease. Of those, 100 volunteered to have regular lumbar punctures to measure the levels of Alzheimer’s-related proteins in the cerebrospinal fluid.

The participants were given multiple-choice scratch-and-sniff tests and asked to identify such scents as bubble gum, gasoline or lemon.

Researchers say the tests revealed that those who had the hardest time correctly identifying the smells also had the more evident biological signs of Alzheimer’s.

“This is the first time that anyone has been able to show clearly that the loss of the ability to identify smells is correlated with biological markers indicating the advance of the disease,” Marie-Elyse Lafaille-Magnan said in a statement. She is a doctoral student at McGill and the first author on the study.

“For more than 30 years, scientists have been exploring the connection between memory loss and the difficulty that patients may have in identifying different odours. This makes sense because it’s known that the olfactory bulb (involved with the sense of smell) and the entorhinal cortex (involved with memory and naming of odours) are among the first brain structures first to be affected by the disease.”

Despite the results, researchers say that more work must be done to see how the loss of the sense of smell relates to the progression of Alzheimer’s.


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Alzheimer’s disease: Targeting enzyme may reverse memory loss

After many years of research, scientists have found that by blocking one specific enzyme, Alzheimer’s-related memory loss could be reversed or prevented.

A new study has suggested that it may be possible to reverse the memory loss that occurs in Alzheimer’s disease with drugs that selectively block the ability of the HDAC2 enzyme to interfere with the communication between brain cells.

Previous attempts to target HDAC2 have not been satisfactory because the drugs that were used also disrupted other functions of the enzyme, producing toxic side effects.

Now, research has shown that blocking a molecule called sp3 that binds to HDAC2 might be a way to stop them both from disrupting synaptic function, or the communication between brain cells that is important for memory.

A report on the study, led by researchers from the Massachusetts Institute of Technology (MIT) in Cambridge, is published in the journal Cell Reports.

Senior author Prof. Li-Huei Tsai, director of the Picower Institute for Learning and Memory at MIT, says that they believe that HDAC2 is a master regulator of genes that control memory and that because its levels are raised in Alzheimer’s disease, it blocks the expression of those genes.

“If we can remove the blockade by inhibiting HDAC2 activity or reducing HDAC2 levels,” Prof. Tsai explains, “then we can remove the blockade and restore expression of all these genes necessary for learning and memory.”

Growing number of people with Alzheimer’s

Alzheimer’s disease is the most common form of dementia, a progressive brain-wasting condition that gradually diminishes people’s ability to think, remember, reason, and make decisions.

As the symptoms worsen, people lose the ability to hold a conversation and respond to what is happening around them.

Experts do not yet know exactly what causes Alzheimer’s disease, but they say that it could be due to several factors that arise differently in different people.

Although it can affect younger people, Alzheimer’s disease is more common among adults aged 60 and older.

Around 5 million people are thought to be living with Alzheimer’s disease in the United States, and this number is expected to rise to 14 million by 2050.

Synaptic plasticity

The new study concerns the disruption of a biological process called synaptic plasticity, which is thought to be important for learning and memory.

Research on what happens at synapses – which are the junctions between brain cells – has revealed that they are “plastic” and not fixed as the soldered joints in electronic circuits are.

Synaptic plasticity is defined as a biological process whereby synapses change over time, depending on specific patterns of activity.

The synaptic changes affect various properties, including the strength of communication between brain cells, which impacts memory.

Prof. Tsai has been researching the role that enzymes called HDACs play in memory loss for over a decade. In 2007, she discovered that blocking HDAC activity in mice could reverse memory loss. There are around a dozen types of HDAC in humans.

HDAC2 blocks memory-related genes

HDACs affect memory by altering histones, which are the proteins that help to package DNA into a structure called chromatin. The effect of HDAC is to condense chromatin, which, in turn, reduces the expression of some genes in the DNA.

In later research, Prof. Tsai found that a particular HDAC in humans called HDAC2 blocked some genes that are important for memory, and that levels of the enzyme are higher in people with Alzheimer’s and also in mouse models of the disease.

Compounds that inhibit HDAC2 have already been tested, but most of these have undesirable side effects. For example, they interfere with HDAC1, which is important for cell proliferation, especially in white and red blood cells.

Therefore, Prof. Tsai and colleagues set out to find a way to target only the activity of HDAC2 that interferes with memory by searching for proteins that help the enzyme to bind to the relevant genes.

Gene expression data from post-mortems of people who did not have Alzheimer’s disease – some whose brains had high and some whose had low levels of HDAC2 – helped the team to find more than 2,000 genes that might be involved with HDAC2 activity.

Sp3 helps HDAC2 to block memory genes

Using other information that they already had about how the genes behave with HDAC2, the team whittled down the candidates to three.

Further tests on these three led them to Sp3, a “transcription factor” molecule that helps HDAC2 to alter chromatin and block the memory genes on the DNA.

Gene expression data from post-mortem samples taken from brains of people who died with Alzheimer’s disease revealed a strong link between levels of HDAC2 and Sp3.

The researchers then showed that reducing sp3 expression in a mouse model of Alzheimer’s disease restored the animals’ ability to form long-term memories.

Our findings indicate that targeting the HDAC2-Sp3 complex could enhance cognitive function without affecting HDAC2 function in other processes.”

The team also found a molecule that might serve as a basis for developing a drug that prevents sp3 from binding to HDAC2 to free up the memory genes. They showed that the molecule does not interfere with cell proliferation, as some other HDAC inhibitors do.

Prof. Tsai says that there is further work to do – such as finding a smaller version of the molecule – before they can settle on a suitable experimental drug candidate.

She also wishes to find out how many other genes might be teaming up with HDAC2, which could lead to other drug targets.


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Revolutionary day care for Alzheimer’s sufferers: Dementia villages

  • An estimated 4 million to 5 million Americans currently have dementia.
  • It remains the most expensive disease in America — a study funded by the National Institute on Aging estimated that in 2010 it cost up to $215 billion a year to care for dementia patients, surpassing heart disease ($102 billion) and cancer ($77 billion).
  • An estimated 5.5 million people in the United States suffer from Alzheimer’s disease, a number that is expected to grow as baby boomers age.
  • Glenner Town Square, a faux mini-town with a 1950s and 1960s look designed for people with dementia, is set to open in San Diego next spring.
Constance Gustke, special to

After working with people with dementia for many years as a licensed nursing home administrator, Scott Tarde was fed up with the lack of affordable care options. So as the CEO of George G. Glenner Alzheimer’s Family Centers, he decided to reimagine a new kind of day care: a faux mini-town with a 1950s and 1960s look designed for people with dementia. His concept is based on reminiscence therapy. His creation is Glenner Town Square, set to open in San Diego next spring.

Reminiscence therapy, developed by psychologist Ellen Langer in 1979, involves the use of past activities, events and experiences with other people, usually with the aid of music and tangible, visual prompts from earlier years, such as photographs and familiar household items.

Glenner Town Square bathes the senses in sights and smells to reflect a person’s younger days. Its 9,000 square feet of space, designed by renowned architect Douglas Pancake, sits in an industrial building and will include a pet store with shelter puppies, department store with clothes and a movie theater with real popcorn. Everyplace is staffed with trained caregivers.

Besides being fun, the retro town, outfitted with gas-lit streetlamps, also has real uses, like triggering positive past memories, say experts, and can help people with dementia feel calmer and need fewer drugs. The goal is to offer a safe location where residents have a structured day, as well as autonomy and independence — giving them a higher quality of life.

“We’re taking people back to their strongest memories,” says Tarde, noting it is a form of time-travel therapy. “Long-term memories are more preserved than short-term ones.”

Tarde, who has 20 years of experience working in the long-term care industry, has targeted a growing demographic in America. An estimated 5.4 million people in the United States suffer from Alzheimer’s disease, a number that is expected to grow as baby boomers age. Even more suffer from a form of dementia. He got the idea for the village after visiting a junior-achievement mini-city in San Diego, where young people discover how the “real world” works by learning how to generate wealth and effectively manage it.

A new day care model

Glenner Town Square fits into a new type of community called dementia villages. They’re attempting to bring fresh models of care, rather than just relying on drugs to take the sharp edges off the disease. The villages also provide safety and connection, which can increase well-being.

Tarde’s creation may be the United States’ first dementia village, though. In 2009 the first kind of residential dementia village appeared in Hogewey, Holland, outside Amsterdam. Inhabitants walk freely among the walled town’s parklike grounds and live in housing units arranged by theme. There are also grocery stores, hair salons and pubs, where the staff works and keeps an eye on the 152 residents The village is about the size of 10 football fields.

Bringing more residential dementia villages to the United States may be a challenge. Hogewey is mainly funded by the Dutch government. Glenner Town Square, conversely, is privately funded by real estate developers Village Holdings, who have anted up $1 million in capital so far. The cost for day visitors, though, is affordable at $95 per day, says Tarde.

An aging demographic

Still, Tarde is optimistic about the power of day programs like Glenner Town Square to transform lives. He believes that medicine alone can’t effectively treat people with Alzheimer’s. “Many people can also stay home if they have the right support,” he says.

There’s such a tsunami of dementia care needed, agrees Donna Surges Tatum, board of directors of the National Certification Board for Alzheimer and Aging CareIn the United States an estimated 4 million to 5 million Americans currently have dementia. It remains the most expensive disease in America — a study funded by the National Institute on Aging estimated that in 2010 it cost up to $215 billion a year to care for dementia patients, surpassing heart disease ($102 billion) and cancer ($77 billion).

In addition, 5.5 million people are currently living with Alzheimer’s. By 2050 that number is projected to reach 13.8 million, according to the Alzheimer’s Association. “It’s expensive to create a whole village,” she says. “And we have such trouble getting care to anyone needs who it these days.”

Reminiscence therapy, which taps into positive back memories, works well, though, she adds. These villages also emphasize personalized care and more engagement, too. “People are currently sometimes drugged more than necessary,” she adds.

Jason Karlawish, a co-director at Penn Memory Center at the University of Pennsylvania, agrees. He advocates for spaces that tap into well-learned memories and comfort. “They should be safe, social and engaged,” he says. Social isolation can even lead to dementia, according to studies, he says.

“People with dementia need to feel like they’re part of the human race,” he adds. “And so we need new approaches that aren’t just biomedical.”

For people used to growing up on farms, Prairie Elder Care in Kansashas a different solution. It’s developing a dementia-care residence farm in Overland Park, Kansas, set to open next year. Called Prairie Farmstead, it has chicken coops and gardens. About 16 residents will always be supervised. But they can also plant tomatoes or roam in a sensory garden with butterflies. The cost is about $7,400 per month.

sensory garden with butterflies. The cost is about $7,400 per month.

“People with dementia need to feel like they’re part of the human race. We need new approaches that aren’t just biomedical.”-Jason Karlawish, associate director,  Penn Memory Center

“Men with dementia can be difficult to engage,” says Mandy Shoemaker, co-owner of Prairie Elder Care. “They end up being on lots of medications for aggressive behaviors.”

The goal, she says, is giving them back control over their lives. “Control is slowly lost over the most basic decisions,” she adds, explaining that with more engagement, they can be more calm and connected.

There are no one-size-fits-all dementia villages, though, says Mario Garrett, professor of gerontology at San Diego State University. “Your 1950s is completely different then my 1950s,” he says. Yet every attempt is a good one, he adds, since people with dementia tend to be ignored.

Even dementia village models will evolve into something better, he says. “People need emotional support.”

— By Constance Gustke, special to


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Ninja drug’ that destroys Alzheimer’s by targeting harmful toxins in brain being developed

The drug – known as the ‘PMN310 antibody’ – is designed to attack only specific toxic proteins which trigger Alzheimer’s disease

SCIENTISTS are developing a “ninja” drug that targets toxic proteins in the brain and stops Alzheimer’s in its tracks.

Early tests show the drug halts the chemical processes that kill brain cells in sufferers and also protects against short-term memory loss.

But unlike other potential treatments, the new method does not have damaging side-effects.

Gene Williams, of proMIS — the Canadian firm behind the drug — said: “This antibody is like a ninja. It comes in and targets only the toxic parts.

“The brain has an amazing rewiring, restoring, regenerative capacity.

“So if you tip the balance back and stop the process [that kills brain cells], you give the brain’s systems a chance to kick in and work. In the early stages, you could see a reversal of symptoms.”

The drug — PMN310 antibody — works by neutralising harmful proteins so the brain can clear them out naturally.

Its success on mice means it will now be trialled in humans. If successful, it could become available in 2025.

Around 850,000 Brits have dementia, and the figure is expected to hit one million within a decade.

There is currently no cure but some drugs can control the symptoms.

Dr Doug Brown, of the Alzheimer’s Society, said: “The disease results from the build-up of two proteins, toxic tangles inside of the cell and amyloid plaques outside of it.

“This promising drug removes amyloid proteins that develop before they become plaques.”


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Two new genes linked to Alzheimer’s risk

Date:July 17, 2017

Source:Cardiff University

Summary:Two genes that influence a person’s risk of developing Alzheimer’s disease have now been identified by a team of researchers.

A team of researchers led by Cardiff University has identified two genes that influence a person’s risk of developing Alzheimer’s disease.

The new finding, which builds on the team’s previous work of identifying 24 susceptibility genes, enables a better understanding of the mechanisms underlying the disease and offers further hope in developing new treatments.



Dr Rebecca Sims from Cardiff University’s School of Medicine said: “In addition to identifying two genes that affect the risk of developing Alzheimer’s disease, our new research reveals a number of other genes and proteins that form a network likely to be important in its development. These particular genes, which suggest that immune cells in the brain play a causal role in the disease, are also very good targets for potential drug treatment.”

Dr Rosa Sancho, Head of Research at Alzheimer’s Research UK, added: “The discovery of new genes is like finding puzzle pieces that biologists can start to fit together to build a complete picture of a disease.

Alzheimer’s Research UK is proud to be supporting scientists at the cutting edge of this work as they continue to make valuable discoveries that are shaping our understanding of the disease. There are currently no treatments to slow the progression of Alzheimer’s and increased investment in research is vital so that we can capitalise on new findings and drive progress for people with the condition and their families.”

The two novel genes, which were not previously considered candidates for Alzheimer’s risk, were identified during a study which compared the DNA of tens of thousands of individuals with Alzheimer’s with aged-matched people who are free from the disease.

There are currently around 850,000 people in the UK with Alzheimer’s. During the course of the disease, proteins build up in the brain to form structures called plaques and tangles. The connections between nerve cells are lost, and eventually the nerve cells die and brain tissue volume is reduced. People with Alzheimer’s also have a shortage of some important chemicals in their brain. These chemical messengers help to transmit signals around the brain. When there is a shortage of them, the signals are not transmitted as effectively.

Dr Doug Brown, Director of Research and Development at Alzheimer’s Society, said: “Over 60% of people with dementia have Alzheimer’s disease, yet despite its prevalence we still don’t fully understand the complex causes of the disease.

“The discovery of two new risk genes for Alzheimer’s is an exciting advance that could help to deepen our understanding of what happens in the brains of people with the disease. These genes reinforce a critical role for special cells in the brain — called microglia — that are responsible for clearing up debris including damaged cells and proteins. Insights like this are vital to help unravel the complexities of Alzheimer’s disease and show researchers where to focus their efforts in the search for new, effective treatments.

“As a funder of this research, we’re delighted to see important progress being made. The UK Dementia Research Institute centre at Cardiff will now build on this discovery to investigate in detail the role of microglia in dementia and ultimately accelerate our progress towards finding a cure.”

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5 Ways to Lower Your Risk for Alzheimer’s Disease

Aluminum is one of the most widely used metals in the world. Consider your morning commute: You hop into your car, where you’re protected from the elements by aluminum body panels. You sip your morning coffee from an aluminum travel mug. You arrive at your desk and pry open your laptop’s aluminum case to check your email.

All of this exposure to aluminum, however, may come at a cost. Research suggests that the metal — a known neurotoxin — builds up in the brain over time, contributing to Alzheimer’s disease and other neurodegenerative conditions.

Writing in a recent issue of The Lancet, neuroscientist Chris Exley made an impassioned case that the modern Aluminum Age, as he calls it, plays a significant role in neurodegenerative diseases. We overlook these risks because aluminum is so common, Exley argued. But there are several explanations for how aluminum may contribute to Alzheimer’s disease. For one, aluminum encourages proteins called amyloids to clump together in the brain, which is a key feature of Alzheimer’s disease. This accumulation may block signals between nerve cells or lead to changes that destroy brain cells.

Aluminum is toxic to the brain, just like mercury, lead, and arsenic, said neurologist David Perlmutter, MD, author of Grain Brain and the Grain Brain Cookbook, in an interview with Yahoo Health. “Over the past 20 years there have been several important research publications that have drawn conclusions relating Alzheimer’s disease to aluminum exposure,” he added. Studies have linked higher aluminum content in drinking water to higher rates of Alzheimer’s disease, for example. And one of the most promising Alzheimer’s therapies involves removing aluminum from the body, providing evidence that the two are closely connected, according to a research review in Frontiers in Aging Neuroscience.

Five Tips to Keep Your Brain Sharp

Because aluminum is so pervasive, it’s nearly impossible to avoid completely. But taking certain steps can significantly lower your risk of developing dementia. “The truth of the matter is that there is no treatment for dementia now or at any time in the foreseeable future, and yet dementia, for the most part, is strongly related to lifestyle choices such as diet, exercise, and even preventing head trauma,” said Perlmutter. “This is powerful information as it puts dementia into the same category as heart disease, for example, in which everyone seems to be very aware of the fact that there are things we can do to prevent that issue.”

If you’re looking to keep your dome healthy, lowering your exposure to aluminum is one course of action, but it’s not the most important one. “These studies on aluminum are intriguing but are in no way as significant as other important and modifiable risk factors for Alzheimer’s disease for which there is profound support in the medical literature,” Perlmutter said.

Follow these tips to reduce your risk for dementia and keep your brain healthy as you age:

1) Watch your blood sugar. “Even mild elevations of blood sugar, well below the threshold for making a diagnosis of diabetes, have now been demonstrated to significantly correlate with the risk of developing dementia,” said Perlmutter. To keep blood sugar under control, limit the amount of carbohydrates you consume and choose healthy fats such as olive oil, coconut oil, nuts, and seeds. If you choose to eat meat, pick grass-fed beef and wild fish, which are higher in heart-healthy omega-3 fatty acids.

2) Keep up with cardio. “Physical activity is a wonderful brain activity,” Douglas Scharre, MD, director of the division of cognitive neurology at Ohio State University, told Yahoo Health. Aerobic activity can make your brain more resilient against developing dementia, studies suggest. Perlmutter recommended at least 20 minutes of sustained aerobic activity each day, such as running, brisk walking, or bike riding.

3) Protect your noggin. Even mild head trauma early in life — a hard knock during a high school football game or a rough crash while rollerblading — can set the stage for dementia later on, Perlmutter said. The simple fix: Always wear a helmet when biking, skateboarding, or rollerblading.

4) Sip mineral water. Silicon is a common mineral in tap and bottled water. It also chemically counteracts aluminum and is given to patients to treat acute aluminum poisoning. A 2013 study in the Journal of Alzheimer’s Disease found that drinking mineral water with silicon helped flush aluminum from the body. Check the label on your bottled water, which should list the minerals it contains.

5) Lower your cholesterol. If your cholesterol levels are high, getting them under control may reduce your risk for dementia. “In studies where large groups of people were followed for many years, people in midlife who were taking cholesterol-lowering statin drugs reduced their risk for dementia and Alzheimer’s disease by about 60 to 70 percent compared to those who weren’t taking statins for elevated cholesterol,” said Scharre. Keep your heart and head happy with these five tips to lower your cholesterol levels.

What Are the 7 Stages of Alzheimer’s Disease?

Stage 1: No Impairment

During this stage, Alzheimer’s disease is not detectable and no memory problems or other symptoms of dementia are evident.

Stage 2: Very Mild Decline

The senior may notice minor memory problems or lose things around the house, although not to the point where the memory loss can easily be distinguished from normal age related memory loss. The person will still do well on memory tests and the disease is unlikely to be detected by physicians or loved ones.

Stage 3: Mild Decline

At this stage, the friends and family members of the senior may begin to notice memory and cognitive problems. Performance on memory and cognitive tests are affected and physicians will be able to detect impaired cognitive function.

Patients in stage 3 will have difficulty in many areas including:

  • finding the right word during conversations
  • remembering names of new acquaintances
  • planning and organizing

People with stage three Alzheimer’s may also frequently lose personal possessions, including valuables.

Stage 4: Moderate Decline

In stage four of Alzheimer’s disease clear cut symptoms of Alzheimer’s disease are apparent. Patients with stage four Alzheimer’s disease:

  • Have difficulty with simple arithmetic
  • May forget details about their life histories
  • Have poor short term memory (may not recall what they ate for breakfast, for example)
  • Inability to manage finance and pay bills

Stage 5: Moderately Severe Decline

During the fifth stage of Alzheimer’s, patients begin to need help with many day to day activities. People in stage five of the disease may experience:

  • Significant confusion
  • Inability to recall simple details about themselves such as their own phone number
  • Difficulty dressing appropriately

On the other hand, patients in stage five maintain a modicum of functionality. They typically can still bathe and toilet independently. They also usually still know their family members and some detail about their personal histories, especially their childhood and youth.

Stage 6: Severe Decline

Patients with the sixth stage of Alzheimer’s disease need constant supervision and frequently require professional care. Symptoms include:

  • Confusion or unawareness of environment and surroundings
  • Major personality changes and potential behavior problems
  • The need for assistance with activities of daily living such as toileting and bathing
  • Inability to recognize faces except closest friends and relatives
  • Inability to remember most details of personal history
  • Loss of bowel and bladder control
  • Wandering

Stages 7: Very Severe Decline

Stage seven is the final stage of Alzheimer’s disease. Because Alzheimer’s disease is a terminal illness, patients in stage seven are nearing death. In stage seven of the disease, patients lose ability to respond to their environment or communicate. While they may still be able to utter words and phrases, they have no insight into their condition and need assistance with all activities of daily living. In the final stages of the illness, patients may lose their ability to swallow.

33 Things People Affected by Alzheimer’s Wish Others Understood

Special Thanks For TheMighty For Pictures
This is what they had to say:

1. “It’s not a part of getting older. There’s a misconception that as you get older you become forgetful and Alzheimer’s is just a continuation of aging, but it’s not. It’s a terrible disease, not a part of aging. It’s not something that’s inevitable or just happens. It’s something we’re trying to fight to bring awareness to because with funding and research there can be hope.” — Stephanie Vasquez

alzheimer's disease quote: It's not a part of getting older.

2. “Be patient with those who suffer. Repeating and forgetting require compassionate responses, not exasperated ones. The disease might hide the person underneath, but there’s still a person in there who needs your love and attention.” — Jamie Calandriello

alzheimer's disease quote: The disease might hide the person underneath, but there's still a person in there who needs your love and attention.

3. “I wish people understood how scary it must be for the person going through it.” — Tbird O’Leary

4. “The disease is still progressing… even though helpful medication exists, there’s still no cure, and we have to keep fighting to find one.” — Sally Noelle

alzheimer's quote: even though helpful medication exists, there's still no cure, and we have to keep fighting to find one.

5. “Just because he looks fine at this moment doesn’t mean it will be the same in five minutes, tonight or tomorrow.” — Nikki Dodson

6. “[People with Alzheimer’s] can’t change the way it makes them act anymore than a cancer patient can keep the cancer cells from spreading.” — Brandyn Shoemaker

alzheimer's quote: [People with Alzheimer's] can't change the way it makes them act anymore than a cancer patient can keep the cancer cells from spreading.

7. “I wish the world knew how heartbreaking it is to stand beside the woman who was the first one to ever call you by your name and realize she doesn’t know who you are. I wish they knew the joy it brings when she suddenly looks up at you after you’ve sat there for hours massaging her hands with lotion and says, ‘I love you, kid.’ It’s extremely hard to mourn the loss of my lifetime companion, my mother, while she’s still alive.” — Nancy Elizabeth Faram

Alzheimer,s On Onthespot247 (1)

8. “Rational thinking is gradually lost with Alzheimer’s, so don’t try to reason with someone with this disorder. Instead, distract them in as gentle a manner as possible. If they get angry or defensive, listen until they’ve said what they need to say. And remember, each time you interrupt or argue, you increase the duration of the conversation without resolving the issue.” — Rex Bierley

9. “It’s not simply forgetting things and people. It’s delusions, hallucinations, anger, poor judgment and personality altering. These things can come and go and the person suffering and their loved ones are on a continual and unknown roller coaster.” — Kimberly Crawford Bowman

alzheimer's quote: It's not simply forgetting things and people.

10. “They’re not doing this on purpose.” — Denise Christy Reich

alzheimer's quote: They're not doing this on purpose.

11. “The reality of this disease is that there’s no remission, there’s no stopping it, there’s no slowing it down, there’s no cure and there are no survivors.” — Suzanne Tackett

alzheimer's quote: The reality of this disease is that there's no remission, there's no stopping it, there's no slowing it down, there's no cure and there are no survivors.

12. “One moment there’s clarity, and they look at you lovingly and say your name. A second later, they look at you frightened or confused because you look familiar or they don’t know you at all.” — Samwise Gamegee Works

13. “Even though behaviors have changed — the person you remember is still in there.” — Roxzan Sukola

alzheimer's quote: Even though behaviors have changed -- the person you remember is still in there.

14. “It’s an epidemic.” — ljsharp

alzheimer's quote: It's an epidemic.

15. “It’s not just memory loss. It robs the person of who they are and the ability to do the most basic tasks.” — Janice La Bella

16. “Losing some memories doesn’t make the still present ones any less important and meaningful.” — Molly Halla

alzheimer's quote: Losing some memories doesn't make the still present ones any less important and meaningful.

17. “I wish people wouldn’t ask how my mom is doing or if she’ll get better. I wish people understood that Alzheimer’s is currently a terminal disease and that caregivers have to watch their loved ones waste away in front of their eyes. It’s often a painful thing to discuss [because] every time they ask, the person is worse than before.” — Michelle Raza

18. “[It’s] devastating when a person who helped raise you completely forgets who you are.” — Odalys De Leon

alzheimer's quote: [It's] devastating when a person who helped raise you completely forgets who you are.

19. “The caregiver, much like with any disability, carries a huge load. They need our support and love.” — Walking With Drake

20. “It’s not your fault.” — Rain Mom

alzheimer's quote: It's not your fault.

21. “It’s the worst. People can’t handle it so they stay away. It’s isolating and lonely.” — Lisa Begley

alzheimer's quote: People can't handle it so they stay away. It's isolating and lonely.

22. “Although your loved one may not remember you or might do things that frustrate you, this is the time when he or she needs you the most. Your loved one needs you to care, to advocate, to be patient, to love and to be vigilant. Don’t turn your back on them.” — Angie Nunez Merryman

alzheimer's quote: Although your loved one may not remember you or might do things that frustrate you, this is the time when he or she needs you the most

23. “I wish doctors would realize that the person with Alzheimer’s has thoughts and feelings about their care. Look the patient in the eye instead of talking to a family member and asking them questions as if the person who has Alzheimer’s isn’t there.” — Cynthia Adams McGrath

24. “You can’t explain what it’s like to mourn someone who’s still alive unless you’ve experienced it firsthand. It truly is the long goodbye.” — Jessica Seay-Soto

alzheimer's quote: You can't explain what it's like to mourn someone who's still alive unless you've experienced it firsthand. It truly is the long goodbye.

25. “[It’s] important to remember those who are suffering from Alzheimer’s as they were before the disease and to keep that person in mind when learning to cope with the disease.” — alib13

26. “The person who has Alzheimer’s knows that pieces of the puzzle are missing, and they are terrified.” — sheilamcphierasak

alzheimer's quote: The person who has Alzheimer's knows that pieces of the puzzle are missing, and they are terrified.

27. “To lose a loved one is always sad, but losing a loved one bit by bit is so sad. It’s horrible to watch someone you love struggling to find words and trying to remember things they realize they should know. You feel so helpless seeing someone looking lost, and you try to take away that fear.” — Jeanette Maxwell

alzheimer's quote: You feel so helpless

28. “I wish people understood the unique experience of grief and loss that comes with Alzheimer’s. My dad was 64 when he was diagnosed, and we’ve been living the loss of him for four years now, even though he is still in our presence. I can still hold my dad’s hand, but I miss him every day.” — Anna Copley

alzheimer's quote: I can still hold my dad's hand, but I miss him every day.

29. “Alzheimer’s patients are people, not patients. They are husbands, wives, brothers, sisters, bosses, employees, sons and daughters, all of whom were robbed of time and the ability to continue to chase their dreams and live their lives freely.” – nicoleadeline

30. “Referencing ‘The Notebook’ doesn’t mean anything to me. [My mother] not recognizing me is the least of my worries because she no longer knows how to swallow.” — fancyy77

alzhiemer's quote: Referencing The Notebook doesn't mean anything to me

31. “It can happen to anyone, young and old… my dad was 49 when diagnosed.” — karli_anne1012

32. “I wish other people would understand that the person affected by Alzheimer’s is not a child or a toddler, as I have heard people casually say to me. Yes, they have childlike qualities, but people have to understand this individual is still an adult, and you can’t treat them as you would a kid. My mom can notice when she’s not getting the respect she deserve.” — a11ofthelights1832

alzheimer's quote: the person affected by Alzheimer's is not a child or a toddler

33. “They may not be able remember who we are, but they feel us just the same.” — Amanda Dillon

Photographer translates the love of great-grandmother with Alzheimer’s through images and words

It was through the photographer Ravena Rose calls “no words” that the images gained as an illustration of love and attention.

What Ravena, to trust us your photos and intimacy he did not know that, through its description, the most beautiful words were spoken.

The Ravena lines are highlighted and, as the photos, say absolutely everything she thought she did not know …

“I’m not very good with words. I do not know to express myself saying or writing … So I read and read a lot and photographer. I am a photographer and I’m doing a photographic series of Alzheimer’s my great-grandmother. “(Ravenna Rosa)

Photography: Ravena Rosa

“The emptiness of knowing that she does not even know who I am doi much. (…) And in the end, I think that those who suffer least is my own grandmother to the disease. After all, she does not even know this sick … “

Photography: Ravena Rosa
Photography: Ravena Rosa
“I do not know what to say, do not know how to act, I only safe in her hands.” Ravena Rosa

“I would very much like to tell my family how I feel, but the way in which I find to express myself is photographing and guess what … no one in my family saw these pictures, so it looks like I do not care for the situation. But the truth is that I care and I care so much. Somewhere else is going through the same situation of not knowing how to deal. ” 

Photography: Ravena Rosa
Photography: Ravena Rosa


Photography: Ravena Rosa

“There are cute photos maquiam disease. It is the harsh reality. Hard, painful, sad .. I feel like shooting every time they caught me fixing his gaze away from her, as if looking for something. And that’s where I record. I feel displaced and lost by the situation. I do not know what to say, do not know how to act, I only safe in her hands. “

Photography: Ravena Rosa
Photography: Ravena Rosa

Thank you, Ravena. We here at CONTI other were very proud of their work and honored to share this feelings so sweet and kind … We are sure that even without most of the memories, her great-grandmother feels the affection is directed to it.

Photography: Ravena Rosa
Photography: Ravena Rosa


Force for family and for all who are going through this battle.

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